Enantioselective Hydrocarbamoylation of Alkenes

The asymmetric hydroaminocarbonylation of olefins represents a straightforward approach for the synthesis enantioenriched amides, but is hampered by necessity to employ CO gas, often at elevated pressures. We herein describe, as an alternative, enantioselective hydrocarbamoylation alkenes leveraging dual copper hydride and palladium catalysis enable use readily available carbamoyl chlorides practical carbamoylating reagent. protocol applicable various types olefins, including alkenyl arenes, terminal alkenes, 1,1-disubstituted alkenes. Substrates containing diverse range functional groups well heterocyclic substructures undergo functionalization provide α- β-chiral amides in good yields with excellent enantioselectivities.